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KMID : 0365819750150010269
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Journal of Pusan Medical College
1975 Volume.15 No. 1 p.269 ~ p.278
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Effect of Quinidine on the Potassium Permeability and Calcium Binding of the Rabbit Erythrocyte Membrane
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Abstract
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This study was undertaken to investigate the effect of quinidine on the K permeability and Ca binding of the rabbit erythrocyte membrane. The results are summarized as follows.
1. Quinidine causes the efflux of K across the rabbit erythrocyte membrane. The osmotic resistance of quinidine-treated erythrocytes is diminished. This diminution of the osmotic resistance is more pronounced by increasing concentration of quinidine and longer incubation time. But osmotic resistance is rather increased in the presence of lower concentration of quinidine.
2. Cysteine and glutathione have little influence on the diminution of osmotic resistance and K efflux induced by quinidine.
3. The addition of PCMB and DNFB augments K outflux markedly while EDTA and EGTA fail to protect against the K efflux induced by quinidine.
4. Quinidine inhibits Na-K ATPase activity of ghosts cells of the rabbit. The inhibition of Na-K ATPase activity by quinidine is not prevented by an addition of cysteine in the incubation medium. 5. Quinidine inhibits Ca binding competitively to rabbit erythrocyte membrane fragments.
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